Hydrogels：5-FU + DDP水凝膠
| 【Numbering】BKMB100019 | 【CAS】CAS | ||
| 【Item No.】BKMB100019-2 | 【specification】 | ||
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Name: 5-FU + DDP hydrogel
Composition: 5-FU, DDP
Grain size: network structure
Application: A degradable thermal hydrogel delivery system for the treatment of gastric cancer
Storage conditions: -4℃
Other instructions: sealed state shelf life for half a year [main advantages] based on temperature sensitive hydrogel delivery system, formed by the polylactic acid and polyethylene glycol three block copolymer (PLEL) as a gel matrix, physical mixing with 5-FU and DDP at room temperature, formed by the 5-FU + DDP / PLEL complex has strong synergistic cell proliferation and proapoptotic effect, also can prolong the local drug retention time, improve the anti-tumor effect, reduce side effects. When the complex is injected into the site after surgical resection of gastric cancer, adjacent tissue and abdominal cavity where cancer cells are prone to remain or metastatic, it can gelate in situ under body temperature, continuously release the wrapped drugs, inhibit the local recurrence of orthotopic tumor and the growth of abdominal metastases, and improve the survival rate.
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Composition: 5-FU, DDP
Grain size: network structure
Application: A degradable thermal hydrogel delivery system for the treatment of gastric cancer
Storage conditions: -4℃
Other instructions: sealed state shelf life for half a year [main advantages] based on temperature sensitive hydrogel delivery system, formed by the polylactic acid and polyethylene glycol three block copolymer (PLEL) as a gel matrix, physical mixing with 5-FU and DDP at room temperature, formed by the 5-FU + DDP / PLEL complex has strong synergistic cell proliferation and proapoptotic effect, also can prolong the local drug retention time, improve the anti-tumor effect, reduce side effects. When the complex is injected into the site after surgical resection of gastric cancer, adjacent tissue and abdominal cavity where cancer cells are prone to remain or metastatic, it can gelate in situ under body temperature, continuously release the wrapped drugs, inhibit the local recurrence of orthotopic tumor and the growth of abdominal metastases, and improve the survival rate.
Title:Sustained co-delivery of 5-fluorouracil and cis-platinum via biodegradable thermo-sensitive hydrogel for intraoperative synergistic combination chemotherapy of gastric cancer
Article link:https://doi.org/10.1016/j.bioactmat.2022.10.004
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